The majority of adults are at risk for CKM Syndrome

InStyle

TOPLINE: Nearly 90% of adults were at risk of developing cardiovascular-kidney-metabolic (CKM) syndrome between 2011 and 2020, according to new research published in JAMA.
METHODOLOGY: In 2023, the American Heart Association defined cardiovascular-kidney-metabolic (CKM) syndrome to acknowledge how heart and kidney diseases, diabetes, and obesity interact and are increasingly co-occurring conditions.
Researchers created categories for risk, ranging from 0 (no risk factors) to 4, using factors such as kidney disease, obesity, and hypertension.
TAKEAWAY: Nearly 90% of participants met the criteria for having a stage of the CKM syndrome, with rates remaining steady throughout the study period.
Almost half of people met the criteria for stage 2 (having metabolic risk factors like hypertension or moderate- to high-risk chronic kidney disease).
14.6% met the criteria for advanced stage 3 (very high-risk chronic kidney disease or a high risk for 10-year CVD) and stage 4 CKM syndrome (established CVD) combined.
Men, adults over age 65 years, and Black individuals were at a greater risk for advanced stages of the CKM syndrome.
IN PRACTICE: “Equitable health care approaches prioritizing CKM health are urgently needed,” the study authors wrote.

NEUTRAL

The headline:.

According to new research published in JAMA, between 2011 and 2020, nearly 90% of adults were at risk of developing cardiovascular-kidney-metabolic (CKM) syndrome.

The methodology.

Cardiovascular, kidney, and metabolic diseases (CKM) are increasingly co-occurring conditions that interact. This was recognized in 2023 when the American Heart Association defined the term “CKM syndrome.”.

Between 2011 and 2020, the National Health and Nutrition Examination Survey provided data to researchers.

Over ten thousand adults over the age of twenty were included in the study; all of them self-reported their status for cardiovascular disease (CVD) and underwent a physical examination as well as fasting laboratory measurements.

Using variables including kidney disease, obesity, and hypertension, researchers developed risk categories that ranged from 0 (no risk factors) to 4.

TAKEAWAY:.

Throughout the duration of the study, rates of nearly 90% of participants who satisfied the criteria for having a stage of the CKM syndrome remained constant.

With metabolic risk factors like hypertension or moderate-to-high-risk chronic kidney disease, nearly half of the population fulfilled the requirements for stage 2.

Of those who met the criteria, 14.6 percent had both stage 4 CKM syndrome (established CVD) and advanced stage 3 (very high-risk chronic kidney disease or a high risk for 10-year CVD) combined.

The advanced stages of the CKM syndrome were more common in men, adults over 65, and Black people.

IN REAL LIFE:.

The authors of the study stated, “Equitable health care approaches prioritizing CKM health are urgently needed.”.

SOURCE:.

Researchers at Harvard Medical School in Boston’s Brigham and Women’s Hospital and cardiologist Muthiah Vaduganathan, MD, MPH, led the study.

LIMITATIONS:.

Statuses related to established CVDs were self-reported. There may have been an underestimation of rates because certain data, such as cardiac biomarkers, echocardiography, and coronary angiography, that would have indicated advanced CKM stages were not available.

DISCLAIMER:.

Bristol Myers Squibb-Pfizer awarded grants to one author in addition to the work that was turned in. Outside of the work that was submitted, Vaduganathan advised and participated in committee trials for a number of pharmaceutical companies, and he also received grants from them. The writers didn’t disclose anything else.

scroll to top